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尤进茂教授简介

信息来源: 暂无 发布日期: 2015-10-08 浏览次数: 2394

 

尤进茂

19634月出生,山东诸城,教授,博导

曲阜师范大学化学与化工学院院长;

2009年始担任山东省生命有机分析重点实验室主任;

2012年始担任山东省绿色天然产物与医药中间体开发高校重点实验室主任;

2006年始被中国科学院西北高原生物研究所聘为博士生导师。

2010年始被山东大学环境科学与工程学院聘为合作博士生导师。

 

荣誉称号与学术兼职情况:

2013年被聘为青海省昆仑学者

2008年入选中国科学院百人计划2010年获得择优支持。

2003年获得山东省十大青年科技创新杰出奖

2013年入选济宁有突出贡献中青年专家。

2012年始担任济宁市政协常委

20102011年连续两年受聘为国家科学技术奖评审委员(聘书号103-10)

2011年始担任国际科技合作计划评审专家

2010年始Global Journal of Analytical Chemistry编委。

2010年始担任《山东化工》编委。

长期担任Journal of Chromatography AAnalytica Chimica ActaFood ChemistryTalantaJournal of Separation ScienceJournal of Chromatography BAnalytical MethodsBiomedical ChromatographyChromatographiaSeparation Science and Technology等多种杂志的特约审稿人

 

学习工作经历

1981.09-1985.07     曲阜师范大学                      本科(学士)

1985.09-1988.07     中科院兰州化物所                  硕士研究生

1996.09-1999.06     中科院兰州化物所                  博士研究生

1999.09-2001.06     大连化学物理研究所                博士后

 2001.09- 至今      曲阜师范大学                      教授

 2003.11- 至今      中科院西高所客座研究员            客座研究员博导

 2009.07- 至今      山东大学博士生合作导师            博导

 

研究方向:

本人长期从事色谱-质谱分析新试剂、新材料、新方法的开发研究,利用开发的新方法对食品、环境、药物、生命等领域的分析工作中,解决当前各领域的重大问题,具体主要开展以下三个方面的工作。

1. 特色药用植物资源开发与保护研究:采用先进的现代分析测试技术对我国特色药用植物进行指纹图谱分析,阐明外界条件对植物形态结构、化学成分和遗传特性的影响,及植物对环境条件的适应和改造作用,为特色药用植物资源开发与保护提供理论依据。

2. 环境有机污染物的高灵敏检测与监控研究。从分发挥新材料的优势,在样品前处理,色谱分离和质谱鉴定等方面研究如多环芳烃 ,多氯联苯 ,以及杀虫剂等持久性有机污染物分析定量新技术,提高方法的灵敏度、准确度和分析通量。

3.蛋白质组学和代谢组学分析新方法及生物标志物筛选研究工作。通过开发新型等重同位素标记试剂,建立组学分析新方法,将新方法用于癌症患者体液、组织、细胞等样品的分析,以期筛选出灵敏特异的肿瘤标志蛋白,提高癌症的诊疗水平。

 

主持项目情况:

12008-2010年,青藏高原天然藏药材化学成分的生物分子识别及新药开发, 中国科学院西北高原生物研究所百人计划(批准号328)(经费70万元 负责人)

22011-2013年,中国科学院百人计划择优支持(编号0216,经费130万元 负责人)

32013-2015年,基于稳定同位素化学标记的定量蛋白质组学新方法研究及其在喉癌生物标志物筛选中的应用(批准号21275089国家自然基金面上项目(经费80万元 负责人)

42015-2018年,基于稳定同位素编码标记的拟靶向代谢组学新方法及其在特色浆果食品组学中的应用(批准号21475075国家自然基金面上项目(经费90万元 负责人)

52009-2012 年,柴达木枸杞利用-柴杞维康软胶囊成果转化,科技部农社口科技人员服务企业行动项目(批准号2009GJG20018 40万元 负责人)

62001-2003年,高灵敏荧光标记试剂在高效液相色谱及毛细管电泳中的应用(批准号20075016国家自然基金面上项目(经费15万元 负责人)

72008-2010年,峰花粉资源评价:有效成分、生态因子及物种间的相关性研究  山东省自然基金面上项目 (批准号Y2007B04)(6万元, 负责人)             

82002-2004年,激光诱导的荧光发光材料在毛细管电泳中的应用山东省青年科学家奖励基金(编号02BS046)(经费6万元 负责人)

92003-2006年,高效辛烷值环戊二烯基三羰基锰的常压生产 (批准号:JD-2015)山东省教委科技重大项目(经费12万元, 负责人)

10、青藏高原植物有效成分的化学全分析中国科学院西北高原生物研究所创新基金(客座研究员, 博士生导师)(经费30万元,负责人)

 

奖励情况:

1201212月;青海省科学技术进步奖 (2013JB-1-02-R07)  一等奖

2200712月;国家科学技术进步奖 2007-J-211-01-R09)二等奖

3200612月;青海省科学技术进步奖 (2006JB-1-02-R09)  一等奖

4201212月;山东省高等学校优秀科研成果(2011BZ30143)  三等奖

5201012月;山东省高等学校优秀科研成果(2010BZ20193)  二等奖

6200812月;山东省高等学校优秀科研成果(2008Z20229)  二等奖 

7200712月;山东省高等学校优秀科研成果(2007Z330273) 二等奖 

8200312月;第二届山东省十大青年科技创新杰出奖

9200910月;课题组撰写的 “牛血清白蛋白中氨基酸组成的高效液相色谱质谱鉴定(2006344):503-507)”获2006-2007年度《分析化学》优秀论文奖 (全国共5篇)

 

培养研究生情况

3位博士生获得西部之光项目支持(王洪伦、李玉林、丁晨旭)

1位博士获得博士研究生国家奖学金(张世娟)

6位博士生获得院长奖学金优秀奖(王洪伦、李玉林、丁晨旭、赵先恩、孙志伟、张世娟)

2位硕生获得地奥奖学金(李国梁,王小艳)

3位博士获得朱李月华奖学金(王小艳、孙志伟、张世娟)

1位博士中国科学院研究生科技创新项目(李国梁)

3位硕士获得山东省优秀硕士学位论文(赵先恩、赵怀鑫、孙海宜)

 

近年发表代表性论文:

1.S.J. Zhang, J.M. You*, S.J. Ning, C.H. Song, and Y.R. Suo, Analysis of estrogenic compounds in environmental and biological samples by liquid chromatography-tandem mass spectrometry with stable isotope-coded ionization-enhancing reagent. Journal of Chromatography A 1280 (2013) 84-91.

2.S.J. Zhang, J.M. You*, G.Y. Zhou, C.L. Li, and Y.R. Suo, Analysis of free fatty acids in Notopterygium forbesii Boiss by a novel HPLC method with fluorescence detection. Talanta 98 (2012) 95-100.

3.S.J. Zhang, J.M. You, Z.W. Sun, C.H. Song, S.J. Ning, C.S. Zhao, and Y.R. Suo, A sensitive method for extraction and determination of endocrine-disrupting compounds from wastewater using 10-ethyl-acridone-2-sulfonyl chloride as pre-column labeling reagent by high-performance liquid chromatography with fluorescence detection. Microchemical Journal 103 (2012) 90-96.

4.S.J. Zhang, J.M. You*, C.H. Song, G. Chen, and Y.R. Suo, Purification and determination of bisphenol A and alkylphenol in river sediments by high performance liquid chromatography with fluorescence detection. Analytical Methods 4 (2012) 4030-4036.

5.H.Y. Sun, J.M. You*, M.H. Yang, and F.L. Qu, Synthesis of Pt/Fe3O4-CeO2 catalyst with improved electrocatalytic activity for methanol oxidation. Journal of Power Sources 205 (2012) 231-234.

6.G. Chen, J. Li, S.J. Zhang, C.H. Song, G.L. Li, Z.W. Sun, Y.R. Suo, and J.M. You*, A sensitive and efficient method to systematically detect two biophenols in medicinal herb, herbal products and rat plasma based on thorough study of derivatization and its convenient application to pharmacokinetics with semi-automated device. Journal of Chromatography A 1249 (2012) 190-200.

7.G. Chen, J. Li, C.H. Song, Y.R. Suo, and J.M. You*, A sensitive and efficient method for simultaneous trace detection and identification of triterpene acids and its application to pharmacokinetic study. Talanta 98 (2012) 101-111.

8.Z.W. Sun, J.M. You*, C.H. Song, and L. Xia, Identification and determination of carboxylic acids in food samples using 2-(2-(anthracen-10-yl)-1H-phenanthro 9,10-d imidazol-1-yl)ethyl 4-methylbenzenesulfonate (APIETS) as labeling reagent by HPLC with FLD and APCI/MS. Talanta 85 (2011) 1088-1099.

9.Z.W. Sun, J.M. You, G.L. Li, X.E. Zhao, Y.R. Suo, and X. Wang, Determination of amino acids in rat brain microdialysate with 1,2,5,6-dibenzocarbazole-9-ethyl chloroformate as labeling reagent by high performance liquid chromatographic fluorescence detection and mass spectrometric identification. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 879 (2011) 1367-1374.

10.G.L. Li, X.L. Zhang, J.M. You*, C.H. Song, Z.W. Sun, L.A. Xia, and Y.R. Suo, Highly sensitive and selective pre-column derivatization high-performance liquid chromatography approach for rapid determination of triterpenes oleanolic and ursolic acids and application to Swertia species: Optimization of triterpenic acids extraction and pre-column derivatization using response surface methodology. Analytica Chimica Acta 688 (2011) 208-218.

11.G.L. Li, J.M. You*, Y.R. Suo, C.H. Song, Z.W. Sun, L.A. Xia, X.N. Zhao, and J.Y. Shi, A developed pre-column derivatization method for the determination of free fatty acids in edible oils by reversed-phase HPLC with fluorescence detection and its application to Lycium barbarum seed oil. Food Chemistry 125 (2011) 1365-1372.

12.G.L. Li, C.H. Song, J.M. You*, Z.W. Sun, L.A. Xia, and Y.R. Suo, Optimisation of red pepper seed oil extraction using supercritical CO2 and analysis of the composition by reversed-phase HPLC-FLD-MS/MS. International Journal of Food Science and Technology 46 (2011) 44-51.

13.G.L. Li, Y.Y. Cui, J.M. You*, X.N. Zhao, Z.W. Sun, L.A. Xia, Y.R. Suo, and X. Wang, Determination of trace amino acids in human serum by a selective and sensitive pre-column derivatization method using HPLC-FLD-MS/MS and derivatization optimization by response surface methodology. Amino Acids 40 (2011) 1185-1193.

14.J.M. You, C.H. Song, T. Yan, Z.W. Sun, Y.L. Li, and Y.R. Suo, An improved reagent for determination of aliphatic amines with fluorescence and online atmospheric chemical ionization-mass spectrometry identification. Analytica Chimica Acta 658 (2010) 98-105.

15.J.M. You, C.H. Song, Y.Y. Fu, Z.W. Sun, L. Xia, Y.L. Xia, and Y.R. Suo, Dual-sensitive probe 1-imidazole-2-(5-benzoacridine)-ethanone for the determination of amines in environmental water using HPLC with fluorescence detection and online atmospheric chemical ionization-mass spectrometry identification. Talanta 80 (2010) 1392-1399.

16.J.M. You, Y.Y. Fu, Z.W. Sun, and Y.R. Suo, 2-(5-Benzoacridine)ethyl-p-toluenesulfonate as sensitive reagent for the determination of bile acids by HPLC with fluorescence detection and online atmospheric chemical ionization-mass spectrometric identification. Analytical and Bioanalytical Chemistry 396 (2010) 2657-2666.

17.J.M. You, H.X. Zhao, Z.W. Sun, L. Xia, T. Yan, Y.R. Suo, and Y.L. Li, Application of 10-ethyl-acridine-3-sulfonyl chloride for HPLC determination of aliphatic amines in environmental water using fluorescence and APCI-MS. Journal of Separation Science 32 (2009) 1351-1362.

18.J.M. You, T. Yan, H.X. Zhao, Z.W. Sun, L. Xia, Y.R. Suo, and Y.L. Li, A sensitive fluorescence reagent for the determination of aldehydes from alcoholic beverage using high-performance liquid chromatography with fluorescence detection and mass spectrometric identification. Analytica Chimica Acta 636 (2009) 95-104.

19.J.M. You, X. Sheng, C.X. Ding, Z.W. Sun, Y.R. Suo, H.L. Wang, and W. Li, Detection of carbohydrates using new labeling reagent 1-(2-naphthyl)-3-methyl-5-pyrazolone by capillary zone electrophoresis with absorbance (UV). Analytica Chimica Acta 609 (2008) 66-75.

20.J.M. You, F. Zhu, W.C. Zhao, X.E. Zhao, Y.R. Suo, and S.J. Liu, Analysis of saturated free fatty acids from pollen by HPLC with fluorescence detection. European Journal of Lipid Science and Technology 109 (2007) 225-236.

21.J.M. You, X.N. Zhao, Y.R. Suo, Y.L. Li, H.L. Wang, and G.C. Chen, Determination of long-chain fatty acids in bryophyte plants extracts by HPLC with fluorescence detection and identification with MS. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 848 (2007) 283-291.

22.J.M. You, W.C. Zhao, L.J. Liu, X.E. Zhao, Y.R. Suo, H.L. Wang, Y.L. Li, and C.X. Ding, Determination of amines using 2-(11H-benzo a carbazol-11-yl) ethyl chloroformate (BCEC-Cl) as labeling reagent by HPLC with fluorescence detection and identification with APCI/MS. Talanta 72 (2007) 914-925.

23.J.M. You, L.J. Liu, W.C. Zhao, X.E. Zhao, Y.R. Suo, H.L. Wang, and Y.L. Li, Study of a new derivatizing reagent that improves the analysis of amino acids by HPLC with fluorescence detection: application to hydrolyzed rape bee pollen. Analytical and Bioanalytical Chemistry 387 (2007) 2705-2718.

24.J.M. You, C.X. Ding, F. Zhu, X.J. Sun, Y.L. Li, and Y.R. Suo, Mass spectrometric identification of multihydroxy phenolic compounds in Tibetan herbal medicines. Chromatographia 65 (2007) 545-553.

25.J.M. You, Y.W. Shi, X.N. Zhao, H.F. Zhang, Y.R. Suo, Y.L. Li, H.L. Wang, and J. Sun, Enhancement of atmospheric pressure chemical ionization for the determination of free and glycine-conjugated bile acids in human serum. Journal of Separation Science 29 (2006) 2837-2846.