课题组主页：https://www.x-mol.com/groups/zhao_yulei

（Email: zhaoyulei86@126.com; ylzhao@qfnu.edu.cn；QQ: 397356474

实验室：实验中心B617；办公室：实验中心B603）

赵育磊，青年教授，绿色有机合成课题组组长，硕士生导师。招生专业：有机化学（学硕）、化学工程（专硕）。主要从事二氧化碳利用、有机电合成、高附加值分子构建研究。2017年6月于华东师范大学获理学博士学位，同年7月加入曲阜师范大学（2017年7月-2019年12月，讲师；2019年12月-至今，副教授；2023年12月-至今，青年教授；2019年7月-至今，有机教研室主任；2022年11月-至今，工会青年工作委员）；主讲《有机化学》、《有机合成化学》、《有机化学实验》、《中级化学实验》等课程；担任国家自然科学基金委项目评议人（通讯评审专家）、美国化学会期刊审稿人、英国皇家化学会期刊审稿人等。获山东省化学化工学会“自然科学奖”二等奖（首位，2022年），山东省优秀硕士学位论文指导教师（2023年），山东省第十届高校青年教师教学比赛优秀奖（2023年）；获曲阜师范大学“优秀研究生指导教师”（2022年、2023年、2024年）、“优秀硕士学位论文指导教师”（2022年）、“优秀学士学位论文指导教师”（2023年）、第十三届青年教师教学比赛一等奖（2023年）、第十二届青年教师教学比赛二等奖（2022年）、第十届青年教师教学比赛三等奖（2020年）等。

科研简介

独立工作后，在《Angew. Chem. Int. Ed.》、《Org. Lett.》、《Org. Chem. Front.》等国际顶级期刊或重要期刊发表研究论文近30篇；申请国家发明专利7项（授权6项，转让1项）。担任国家自然科学基金委项目评议人（通讯评审专家）、美国化学会期刊审稿人、英国皇家化学会期刊审稿人等。

主持“国家自然科学基金面上项目”（2024-2027；项目编号：22371164）；

主持“山东省自然科学基金面上项目”（2022-2024；项目编号：ZR2021MB136）；

主持“山东省自然科学基金青年类项目”（2018-2020；项目编号：ZR2018BB026）；

主持“曲阜师范大学科研启动基金项目”（2017-至今）；

主持“曲阜师范大学教学改革项目”（项目编号：18jg14）；

指导“国家级大创项目”（2024-2026，项目编号：202410446004）；

指导“国家级大创项目”（2021-2023，项目编号：202110446051）；

指导“省级大创项目”（2019-2021，项目编号：S201910446084）；

指导“曲阜师范大学大创项目”（2018-2019，项目编号：2018A042）；

此外，参与完成国家级、省级科研项目若干；

教学简介

至2024年5月：课题组第一届硕士生（2022届，郭旭强）被南开大学录取为博士研究生，获评校级“优秀硕士学位论文”（全院3人，全校33人）、“圣地英才奖”，获“2023年山东省优秀硕士学位论文”（全院2人，全校23人）；课题组第二届硕士生（2023届，李帅）被华东师范大学聘为科研助理；课题组第三届硕士生（2024届，范宇航）被吉林大学录取为博士研究生，获“圣地英才奖”。小组科研训练本科生王慧敏（2023届）获曲阜师范大学“优秀学士学位论文”（全院10人）；此外，小组本科生保送天津大学（2020届，郭慧妍）、华东师范大学（2022届，冯楠；2023届，康欣）、南开大学（2024届，曹骏）读研；考入华东师范大学（张正、刘旭、王宗康、司志姚、孙莹、丁鑫、师欣蕊、张瑞华、蒋蒙蒙、王慧敏、孟晓含、林雨濛）、浙江大学（高博文）、北京科技大学（卢旭）、西北农林科技大学（杜钰兰）、中国海洋大学（刘璐）、东华大学（李曼）、东北师范大学（李瑞）、华中师范大学（傅德斌）、天津大学（苏琦）、大连理工（焦鑫）、山东师范大学（刘晓诺）等高校攻读研究生者40余人（以上名单按考入时间先后排序）。

每年招收硕士研究生2-3名，支持并推荐研究生深造读博！每年招收5-8名本科生进行毕业设计；欢迎本科生加入课题组开展科研训练！欢迎踏实、勤奋、认真、努力的学生加入！

独立工作后发表学术论文（至2024年03月）

【最新动态见课题组（x-mol）主页：https://www.x-mol.com/groups/zhao_yulei】

[1] Ruiqing Wang, Lingkai Kong, Xinyu Zong, Minghui Zhang, Wenyi Chen, Yaxin Liu, Lingjuan Ma*, Yulei Zhao*, Diazenylation of active methyne compounds via arylazo sulfones, Org. Chem. Front. 2024, 11, 2815-2820. (中科院SCI一区)

Highlighted by: Frontiers Journals: https://mp.weixin.qq.com/s/cz-4vi8_cj0X0QAssVKkWA

[2] Yuhang Fan, Zhanshuo Zhang, Yulei Zhao,* Self-detachable protecting group function of CO₂ in the electrochemical reduction of aryl azides, Org. Chem. Front. 2024, 11, 1184-1191. (中科院SCI一区)

[3] Yuhang Fan, Chao Chen, Zhanshuo Zhang, Xiaohan Meng, Xiaonuo Liu, Jun Cao, Yuan-Ye Jiang,* Yulei Zhao,* CO₂ Transient Promotion Function Enabled the Selective Electrochemical Transformation of Imines, Org. Lett. 2023, 25, 9202–9206. (自然指数期刊，中科院SCI一区)

[4] Xiaotong Dong, Xiaonuo Liu, Lei Wang, Yixuan Zhang, Jiale Li, Laijin Tian, Yulei Zhao,* Catalyst-Free gem-Difluorination/Spirocyclization of Indole-2-carboxamides: Synthesis of C2-Spiroindoline Derivatives, Org. Lett. 2023, 25, 8771–8776. (自然指数期刊，中科院SCI一区)

[5] Yulei Zhao,* Shuai Li, Yuhang Fan, Jun Cao, Xiaotong Dong, Ruiqing Wang, Laijin Tian, C_sp3–H Imination Using Arylazo Sulfone as a N Source: An Approach to Access Imines, Org. Lett. 2023, 25, 5911-5915. (自然指数期刊，中科院SCI一区)

Highlighted by:

CBG资讯“人物与科研”栏目：https://mp.weixin.qq.com/s/q1IuasuuJI_jGVlSINyJDw

Organic Chemistry Portal: https://www.organic-chemistry.org/abstracts/lit9/156.shtm

[6] Yulei Zhao,* Shuai Li, Yuhang Fan, Chao Chen, Xiaotong Dong, Ruiqing Wang, Yuan-Ye Jiang,* Mild diazenylation of C_sp2-H and C_sp3-H bond via arylazo sulfones, Org. Chem. Front. 2023, 10, 5923-5932. (中科院SCI一区)

[7] Yulei Zhao*, Xuqiang Guo, Shuai Li, Yuhang Fan, Guo-Cui Ji, Mengmeng Jiang, Yin Yang, Yuan-Ye Jiang*, Transient Stabilization Effect of CO₂ in the Electrochemical Hydrogenation of Azo Compounds and the Reductive Coupling of α-Ketoesters, Angew. Chem. Int. Ed. 2022, 61, e202213636. (自然指数期刊，中科院SCI一区) （感谢蒋原野副教授（共同通讯作者）和研究生纪国翠提供的计算支持！感谢南开大学杨茵博士提供的EPR支持！感谢课题组硕士生郭旭强、李帅、范宇航和本科生蒋蒙蒙在实验方面的辛苦付出！）

Highlighted by:

CBG资讯“人物与科研”栏目：https://www.chembeango.com/zixun/57304c5

研之成理：https://mp.weixin.qq.com/s/-QO53jQy8UcswvhXA8hx2w

《化学与材料科学》：https://mp.weixin.qq.com/s/fAb9Q7jCY9_33-aV2r6xeQ

WileyChem：https://mp.weixin.qq.com/s/g3FIWAtGQ5CsP8nSc7jfaw

《大众日报》：http://dzrb.dzng.com/articleContent/37_1068580.html

和曲阜师范大学主页：https://www.qfnu.edu.cn/info/1383/45436.htm等网络平台。

[8] Yulei Zhao*, Huimin Wang, Xin Kang, Ruihua Zhang, Nan Feng, Qi Su, Controllable Methylenation with Ethylene Glycol as Methylene Source: Bridging Enaminones and Synthesis of Tetrahydropyrimidines, Org. Chem. Front. 2022, 9, 5935-5941. (中科院SCI一区)

[9] Yulei Zhao*, Yuhang Fan, Xiaohan Meng, Xin Kang, Zhongyin Ji, Shina Yan, Laijin Tian, Electrochemical Cyclization of Alkynyl Enaminones: Controllable Synthesis of Indeno[1,2-c]pyrroles or Indanones, J. Org. Chem. 2022, 87, 11131-11140. (中科院SCI二区, TOP期刊)

[10] Yulei Zhao*, Shuai Li, Yuhang Fan, Huimin Wang, Xin Kang, Zhongyin Ji, Laijin Tian, Synthesis of Polycyclic 3,3ʹ-Biindoles via AgOTf-Catalyzed Nucleophilic Addition and Cycloisomerization, J. Org. Chem. 2022, 87, 6418-6425. (中科院SCI二区, TOP期刊)

[11] Yulei Zhao*, Shuai Li, Jinjie Cui, Huimin Wang, Xin Kang, Yan Wang, Laijin Tian, Selectfluor-Mediated Oxidative Dehydrogenation of Hydrazines: A Process for the Synthesis of Azo Compounds, Synthesis-Stuttgart 2022, 54, 5245-5252.（被选为“封面文章”，中科院SCI四区）

[12] Xuqiang Guo, Xuejun Sun, Mengmeng Jiang, Yulei Zhao*, Switchable Synthesis of Sulfoxides, Sulfones and Thiosulfonates through Selectfluor-Promoted Oxidation with H₂O as O-Source, Synthesis-Stuttgart 2022, 54, 1996-2004. (中科院SCI四区)

[13] Yulei Zhao*, Xuqiang Guo, Shuai Li, Yuhang Fan, Xuejun Sun, Laijin Tian, PhB(OH)₂ Promoted Electrochemical Sulfuration-Formyloxylation of Styrenes and Selectfluor Mediated Oxidation-Olefination, Org. Lett. 2021, 23, 9140–9145. (自然指数期刊，中科院SCI一区)

[14] Yulei Zhao*, Xuqiang Guo, Ruihua Zhang, Shuai Li, Tingting Chen, Xuejun Sun*, CF₃CO₂H-Catalyzed Synthesis of 3-Alkynylpyrrole Derivatives and Their Controlled Reduction, J. Org. Chem. 2021, 86, 15568-15576. (中科院SCI二区, TOP期刊)

[15] Yulei Zhao*, Shuai Li, Yuhang Fan, Xuqiang Guo, Xin Jiao, Laijin Tian, Xuejun Sun*, Synthesis of 10H-indolo[1,2-a]indole Derivatives via Intramolecular Cycloaddition and H-Migration, Eur. J. Org. Chem. 2021, 4358–4363. (中科院SCI三区)

[16] Xiao-Yuan Cui, Yu-Lei Zhao, Yan-Mei Chen, Su-Zhen Dong*, Feng Zhou, Hai-Hong Wu*, Jian Zhou*, Au-Catalyzed Formal Allylation of Diazo(thio)oxindoles: Application to Tandem Asymmetric Synthesis of Quaternary Stereocenters, Org. Lett. 2021, 23, 4864–4869. (自然指数期刊，中科院SCI一区)

[17] Duyi Shen*, Hongyan Wang, Yanan Zheng, Xinjing Zhu, Peiwei Gong, Bin Wang, Jinmao You, Yulei Zhao*, Mianran Chao*, Catalyst-Free and Transition-Metal-Free Approach to 1,2-Diketones via Aerobic Alkyne Oxidation, J. Org. Chem. 2021, 86, 5354-5361. (中科院SCI二区, TOP期刊)

[18] Yulei Zhao*, Xuqiang Guo, Xin Ding, Zheng Zhou, Man Li, Nan Feng, Bowen Gao, Xu Lu, Yunlin Liu, Jinmao You, Reductive CO₂ Fixation via the Selective Formation of C−C Bonds: Bridging Enaminones and Synthesis of 1,4-Dihydropyridines, Org. Lett. 2020, 22, 8326−8331. (自然指数期刊，中科院SCI一区)

[19] Yulei Zhao*, Xuqiang Guo, Zhiyao Si, Yanan Hu, Ying Sun, Yunlin Liu, Zhongyin Ji, Jinmao You*, Hydrosilane-Assisted Synthesis of Urea Derivatives from CO₂ and Amines, J. Org. Chem. 2020, 85, 13347−13353. (中科院SCI二区, TOP期刊)

[20] Yulei Zhao*, Xu Liu, Lijun Zheng, Yulan Du, Xinrui Shi, Yunlin Liu, Zhengquan Yan*, Jinmao You*, Yuanye Jiang*, One-Pot Methylenation−Cyclization Employing Two Molecules of CO₂ with Arylamines and Enaminones, J. Org. Chem. 2020, 85, 912-923. (中科院SCI二区, TOP期刊)

[21] Yulei Zhao*, Xuqiang Guo, Yulan Du, Xinrui Shi, Shina Yan, Yunlin Liu, Jinmao You*, Synthesis of fused-tetrahydropyrimidines: one-pot methylenation-cyclization utilizing two molecules of CO₂, Org. Biomol. Chem. 2020, 18, 6881–6888. (中科院SCI三区)

[22] Yuanyang Mu, Yang Yuan, Ye Wang, Murong Xu, Ye Feng, Yulei Zhao*, Yanzhong Li*, Synthesis of indoline-fused eight-membered azaheterocycles through Zn-catalyzed dearomatization of indoles and subsequent base-promoted C-C activation, Org. Biomol. Chem. 2020, 18, 6916–6926. (中科院SCI三区)

[23] Yulei Zhao*, Xuqiang Guo, Zongkang Wang, Duyi Shen*, Tingting Chen, Nan Wu, Shina Yan, Jinmao You, TBAF-Catalyzed Cyclization Reactions of o-(Alkynyl)phenyl Propargyl Alcohols with Malonate Esters: A Possible Cation–π Interaction as The Activation Approach, Eur. J. Org. Chem. 2020, 978–984. (中科院SCI三区)

[24] Yulei Zhao*, Zheng Zhang, Xu Liu, Zongkang Wang, Ziping Cao, Laijin Tian, Mingbo Yue, Jinmao You*, TBAF-Catalyzed O‑Nucleophilic Cyclization of Enaminones: A Process for the Synthesis of Dihydroisobenzofuran Derivatives, J. Org. Chem. 2019, 84, 1379−1386. (中科院SCI二区, TOP期刊)

[25] Shu-Jie Chen, Guo-Shu Chen, Jia-Wei Zhang, Zhao-Dong Li, Yu-Lei Zhao, Yun-Lin Liu*, Phosphine-catalyzed [3+2] cycloadditions of trifluoromethyl enynes/enediynes with allenoates: access to cyclopentenes containing a CF₃-substituted quaternary carbon center, Org. Chem. Front. 2020, 7, 3399-3405. (中科院SCI一区)

[26] Jian Luo, Guo-Shu Chen*, Shu-Jie Chen, Zhao-Dong Li, Yu-Lei Zhao, Yun-Lin Liu*, One-Pot Tandem Protocol for the Synthesis of 1,3-Bis(βaminoacrylate)-Substituted 2-Mercaptoimidazole Scaffolds, Adv. Synth. Catal. 2020, 362, 3635– 3643. (中科院SCI二区, TOP期刊)

[27] Jian Luo, Yu-Bo Fang, Xiang-Yu Mao, Meng Yang, Yu-Lei Zhao, YunLin Liu*, Guo-Shu Chen*, Yong-Fei Ji*, Organocatalytic Asymmetric Cyclization Reaction of 2-Alkynyl3,3-Difluoro-3H-Indoles and 2-Mercaptoimidazoles: Access to gem-Difluorinated C2-Spiro Indolines, Adv. Synth. Catal. 2019, 361, 1408-1413. (中科院SCI二区, TOP期刊)

[28] Zhengquan Yan*, Hua Yuan, Qi Zhao, Lin Xing, Xiaoyu Zheng, Weiguo Wang, Yulei Zhao, Yang Yu, Lei Hu* Wenli Yao, Recent developments of nanoenzyme-based colorimetric sensors for heavy metal detection and the interaction mechanism, Analyst 2020, 145, 3173-3187. (中科院SCI二区)

[29] Ling Zhu, Ling-Jun Liu, Yuan-Ye Jiang*, Peng Liu, Xia Fan, Qi Zhang, Yulei Zhao, Siwei Bi*, Mechanism and Origin of Ligand-Controlled Chemo- and Regioselectivities in Palladium-Catalyzed Methoxycarbonylation of Alkynes, J. Org. Chem. 2020, 85, 7136-7151. (中科院SCI二区, TOP期刊)

独立工作后参与的教学类论文

[30] 颜世娜，孙敏，许丽荣，孙学军，赵育磊*，师范院校有机化学实验教学改革探讨，《科技视界》，2022，第25期，100-112。

[31] 颜世娜，杨加芹，许丽荣，曹子平，赵育磊*，高师有机化学实验开展课程思政的探索与实践，《广东化工》，2024，第51卷，第513期，199-200。

独立工作前部分研究论文

[32] Yulei Zhao, Murong Xu, Zhong Zheng, Yang Yuan, Yanzhong Li*, Tertiary amine self-catalyzed intramolecular C_sp3-H functionalization with in situ generated allenes for the formation of 3-alkenyl indolines, Chem. Commun. 2017, 53, 3721-3724. (自然指数期刊，中科院SCI一区)

[33] Yu-Lei Zhao, Zhong-Yan Cao, Xing-Ping Zeng, Jia-Meng Shi, Yi-Hua Yu, Jian Zhou*, Asymmetric sequential Au(I)/chiral tertiary amine catalysis: an enone-formation/cyanosilylation sequence to synthesize optically active 3-alkenyloxindoles from diazooxindoles, Chem. Commun. 2016, 52, 3943-3946. (自然指数期刊，中科院SCI一区)

[34] Zhong-Yan Cao^#, Yu-Lei Zhao^#, Jian Zhou*, Sequential Au(I)/chiral tertiary amine catalysis: a tandem C–H functionalization of anisoles or a thiophene/asymmetric Michael addition sequence to quaternary oxindoles, Chem. Commun. 2016, 52, 2537-2540. (自然指数期刊，中科院SCI一区)

[35] Yulei Zhao, Yang Yuan, Xiaoyu Wang, Yanzhong Li*, Synthesis of Polycyclic Benzo[b]indolo[3,2,1-de]acridines via Sequential Allenylation, Diels−Alder Cyclization, and Hydrogen Migration Reaction, J. Org. Chem. 2017, 82, 11198-11205. (中科院SCI二区, TOP期刊)

[36] Yulei Zhao, Yang Yuan, Murong Xu, Zhong Zheng, Runhua Zhang, Yanzhong Li*, Selective synthesis of pyrrolo[1,2-a]azepines or 4,6-dicarbonyl indoles via tandem reactions of alkynones with pyrrole derivatives, Org. Biomol. Chem. 2017, 15, 6328-6332. (中科院SCI二区)

[37] Yulei Zhao, Yang Yuan, Lingkai Kong, Fangfang Zhang, Yanzhong Li*, Synthesis of 1-Alkyl-3-(2-oxo-2-aryl/alkyl-ethyl)indolin-2-ones through Gold/Brønsted Acid Relay Actions: Observation of Selective C=C Bond Cleavage of Enaminones, Synthesis-Stuttgart 2017, 49, 3609-3618. (中科院SCI三区)

[38] Yulei Zhao, Qizhao Duan, Yuanyuan Zhou, Qiyi Yao, Yanzhong Li*, Gold-catalyzed chemo- and diastereoselective C(sp²)–H functionalization of enaminones for the synthesis of pyrrolo[3,4-c]-quinolin-1-one derivatives, Org. Biomol. Chem. 2016, 14, 2177-2181. (中科院SCI二区)

[39] Yulei Zhao, Fangfang Zhang, Wenjun Yao, Chengyu Wang, Yuanyuan Liu*, Yanzhong Li*, Base-Promoted Approach to Highly Functionalized Conjugated Dienes through Enamine Migration, Eur. J. Org. Chem. 2015, 7984-7991. (中科院SCI三区)

[40] Yun-Lin Liu, Xin Wang, Yu-Lei Zhao, Feng Zhu, Xing-Ping Zeng, Long Chen, Cui-Hong Wang, Xiao-Li Zhao, Jian Zhou*, One-Pot Tandem Approach to Spirocyclic Oxindoles Featuring Adjacent Spiro-Stereocenters, Angew. Chem. Int. Ed. 2013, 52, 13735-13739. (自然指数期刊，中科院SCI一区)

[41] Wei-Ming Gao, Jin-Sheng Yu, Yu-Lei Zhao, Yun-Lin Liu, Feng Zhou, Hai-Hong Wu*, Jian Zhou*, Highly enantioselective Michael addition of 3-arylthio- and 3-alkylthiooxindoles to nitroolefins catalyzed by a simple cinchona alkaloid derived phosphoramide, Chem. Commun. 2014, 50, 15179-15182. (自然指数期刊，中科院SCI一区)

[42] Fangfang Zhang, Zhengchen Qin, Lingkai Kong, Yulei Zhao, Yuanyuan Liu, Yanzhong Li*, Metal/Benzoyl Peroxide (BPO)-Controlled Chemoselective Cycloisomerization of (o‑Alkynyl)phenyl Enaminones: Synthesis of α‑Naphthylamines and Indeno[1,2‑c]pyrrolones, Org. Lett. 2016, 18, 5150-5153. (自然指数期刊，中科院SCI一区)

[43] Yuanyuan Zhou, Xianghua Tao, Qiyi Yao, Yulei Zhao, Yanzhong Li*, Insertion of Isolated Alkynes into Carbon–Carbon s-Bonds of Unstrained Cyclic b-Ketoesters via Transition-Metal-Free Tandem Reactions: Synthesis of Medium-Sized Ring Compounds, Chem. Eur. J. 2016, 22, 17936-17939. (中科院SCI二区)

独立工作后代表性专利

【1】 赵育磊，刘旭，郑丽君，郭旭强，杜钰兰，师欣蕊，万竹婷，陈婷婷，丁鑫，周政，一种四氢嘧啶类衍生物的合成方法，专利号：ZL201910657604.6，授权号：CN110218190B，申请日：2019.07.20，授权日：2021.02.12

【2】 赵育磊，王宗康，郭旭强，陈婷婷，张瑞华，冯楠，吕梦，胡雅楠，孙莹，董永平，何梦瑶，刘振翠，一种异苯并呋喃双酯类衍生物及其合成方法，专利号：ZL201910882550.3，授权号：CN110669030B，申请日：2019.09.18，授权日：2021.05.18

【3】 赵育磊，司志姚，郭旭强，胡雅楠，孙莹，董永平，高博文，卢旭，武博翰，成倩倩，臧青，一种脲类衍生物及其合成方法，专利号：ZL201911069763.0，授权号：CN110683969B，申请日：2019.11.05，授权日：2022.05.17

【4】 赵育磊，张正，王宗康，司志姚，傅德斌，刘旭，郑丽君，李曼，李慧婷，孟占乾，刘璐，李瑞，吴楠，一种1,3-二氢异苯并呋喃衍生物及其合成方法和应用，专利号：ZL201810991246.8，授权号：CN108947945B，申请日：2018.08.28，授权日：2022.08.02

【5】 赵育磊，李曼，丁鑫，周政，冯楠，卢旭，高博文，郭旭强，杜钰兰，师欣蕊，陈婷婷，一种1,4-二氢吡啶类衍生物及其合成方法，专利号 ZL201911334044.7，授权号：CN110981790B，申请日：2019.12.23，授权日：2022.10.14

【6】 赵育磊，李帅，蒋蒙蒙，王慧敏，康欣，苏琦，崔金洁，焦鑫，孟晓含，纪淑欣，秦誉真，唐堉森，一种稠环3,3’-联吲哚衍生物及其合成方法，申请号：202210090490.3，申请日：2022.01.25

【7】 赵育磊，王慧敏，康欣，冯楠，张瑞华，苏琦，陈丽荟，陈文静，一种四氢嘧啶类衍生物及其制备方法，专利号：ZL202210873953.3，授权号：CN115057821B，申请日：2022.07.21，授权日：2024.06.14。