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一、简况
孔维恒,博士,硕士研究生导师。曲阜师范大学化学与化工学院青年副教授。2021年博士毕业于湖南大学化学化工学院。主要从事功能性纳米药物载体及药物递送体系的设计与构筑、自组装纳米材料合成及其在生物医学诊疗中的应用研究。Biosensors期刊客座编辑。以第一作者或共同第一作者身份发表了SCI论文多篇。主讲本科生《药物分析》、《药剂学》、《制药工程专业实验》等课程。
二、教育与工作履历
2021.10 –今 曲阜师范大学 化学与化工学院 讲师
2017.09 – 2021.06 湖南大学 化学 博士
2014.09 – 2017.06 曲阜师范大学 化学 硕士
2010.09 – 2014.06 曲阜师范大学 应用化学 学士
三、主持及参与的科研项目
国家自然科学基金委员会,青年科学基金项目,22207062,配位驱动的模块化核酸药物载体构建及抗肿瘤作用研究,2023-01-01 至 2025-12-30,30万元,在研,主持。
山东省自然科学基金委员会,青年科学基金项目,ZR2022QB209,配位驱动的自组装纳米载体用于siRNA体内递送及生物应用研究,2023-01-01 至 2025-12-30,15万元,在研,主持。
湖南省教育厅,研究生科研创新项目,CX20190270,金属有机框架复合纳米材料的制备及其在肿瘤治疗中的应用研究,2019-07 至 2021-06,1万元,结题,主持。
国家自然科学基金委员会,青年科学基金项目,21807030,DNA中腺嘌呤甲基化修饰的生物学效应及其修复机制的研究,2019-01-01 至 2021-12-31,25万元,结题,参与。
国家自然科学基金委员会,面上项目,21677085,基于稳定同位素质谱探针标记的食品污染物检测新技术及膳食暴露评估研究,2017-01-01 至 2020-12-31,66万元,结题,参与。
四、代表性研究成果
1. Yan Zhao; Xinquan Yu; Weiheng Kong; Rong-Mei Kong; Ensheng Zhang; Lian Xia; Jing Zhang; Fengli Qu and Weihong Tan; Responsive calcium-derived nanoassemblies induce mitochondrial disorder to promote tumor calcification, Chemical Science. 2023, 23;14(35):9 350-9359.
2. Yan Zhao; Xinquan Yu; Xiao Liu; Dailiang Zhang; He Li; Hanlin Zhou; Weiheng Kong and Fengli Qu; ClO- Induced Dual-Excitation Fluorescent Probes Responding to Diverse Testing Modes with Ratio Methodology, Analytical Chemistry. 2023, 9;95(18):7170-7177.
3. Lingdong Zhang; Xiuli Wang; Weiheng Kong; Yan Zhao; Lian Xia and Fengli Qu, An enhanced-stability metal–organic framework of NH2-MIL-101 as an improved fluorescent and colorimetric sensor for nitrite detection based on diazotization reaction, Sensors & Actuators: B. Chemical, 386(2023), 133768.
4. Yan Zhao; Changtong Lu; Xian-En Zhao; Weiheng Kong; Shuyun Zhu and Fengli Qu. A T-rich nucleic acid-enhanced electrochemical platform based on electroactive silver nanoclusters for miRNA detection, Biosensors and Bioelectronics, 208(2022), 114215.
5. Weiheng Kong; Yongqin Ji; Xiaowen Zhu; Xiaoxia Dai; Changjun You; Development and Application of a Chemical Labeling‐Based Biosensing Assay for Rapid Detection of 8‐Oxoguanine and Its Repair in vitro and in Human Cells, Chinese Journal of Chemistry, 2022, 40: 2329-2334.
6. Weiheng Kong; Linlin Wang; Yan Zhao; Hong Chen; Yunming Liu; Xiaoyan Han; Ying Yang; Juan Wang; Changjun You; Yanlan Liu; Sequential module coordination-driven programmable function switch of metal-molecule nanoframeworks for cancer theranostics, Nano Today, 2021, 38: 101126.
7. Yan Zhao; Weiheng Kong; Peng Wang; Guosheng Song; Zhi-Ling Song; Yue Yang; Youjuan Wang;Baoli Yin; Pengfei Rong; Shuangyan Huan; Xiao-Bing Zhang; Tumor-Specific Multipath Nucleic Acid Damages Strategy by Symbiosed Nanozyme@Enzyme with Synergistic Self-Cyclic Catalysis., Small, 2021, 17: 2100766.
8. Weiheng Kong; Di Wu; Na Hu; Ning Li; Chunji Dai; Xuefeng Chen; Yourui Suo; Guoliang Li; Yongning Wu; Robust hybrid enzyme nanoreactor mediated plasmonic sensing strategy for ultrasensitive screening of anti-diabetic drug, Biosensors and Bioelectronics, 2018, 99(2018): 659.
9. Kong, Weiheng; Wu, Di; Li, Guoliang; Chen, Xuefeng; Gong, Peiwei; Sun, Zhiwei; Chen, Guang; Xia, Lian; You, Jinmao; Wu, Yongning; A facile carbon dots based fluorescent probe for ultrasensitive detection of ascorbic acid in biological fluids via non-oxidation reduction strategy, Talanta, 2017, 165: 677-684.
10. Kong, Weiheng; Wu, Di; Xia, Lian; Chen, Xuefeng; Li, Guoliang; Qiu, Nannan; Chen, Guang;Sun, Zhiwei; You, Jinmao; Wu, Yongning; Carbon dots for fluorescent detection of alpha-glucosidase activity using enzyme activated inner filter effect and its application to anti-diabetic drugdiscovery, Analytica Chimica Acta, 2017, 973: 91-99.
五、授权专利和学术奖励
一种基于铁和多巴胺配位的纳米颗粒光热转换材料及其制备方法和应用,专利号:ZL 2019 1 1309412.2
一种具有类酶活性的二维Cu-CAT纳米片及其制备方法与应用,专利号:专利号:ZL 2022 1 1125804.5
六、联系方式
E-mail:kongweiheng@qfnu.edu.cn
通讯地址:山东省曲阜市静轩西路57号,曲阜师范大学,化学与化工学院
邮政编码:273165